| 11/09/2021 | Empoli vs. Venezia | ||
| 11/09/2021 | Naples vs. Juventus | ||
| 11/09/2021 | Atalanta vs. Fiorentina | ||
| 12/09/2021 | Sampdoria vs. Inter Milan | ||
| 12/09/2021 | Spezia vs. Udinese | ||
| 12/09/2021 | Torino vs. Salernitana | ||
| 12/09/2021 | Cagliari vs. Genoa | ||
| 12/09/2021 | Milan AC vs. Lazio | ||
| 12/09/2021 | AS Rome vs. Sassuolo | ||
| 13/09/2021 | Bologne vs. Hellas Verone |