| 11/09/2021 | Brentford vs. Brighton Hove Albion | ||
| 11/09/2021 | Southampton vs. West Ham | ||
| 11/09/2021 | Leicester City vs. Manchester City | ||
| 11/09/2021 | Chelsea vs. Aston Villa | ||
| 11/09/2021 | Crystal Palace vs. Tottenham | ||
| 11/09/2021 | Manchester United vs. Newcastle | ||
| 11/09/2021 | Arsenal vs. Norwich City | ||
| 11/09/2021 | Watford vs. Wolverhampton | ||
| 12/09/2021 | Leeds vs. Liverpool | ||
| 13/09/2021 | Everton vs. Burnley |