| 11/09/2021 | SC Cambuur vs. Go Ahead Eagles | ||
| 11/09/2021 | AZ Alkmaar vs. PSV | ||
| 11/09/2021 | FC Twente vs. FC Utrecht | ||
| 11/09/2021 | PEC Zwolle vs. Ajax | ||
| 12/09/2021 | NEC vs. Willem II | ||
| 12/09/2021 | Sparta Rotterdam vs. Fortuna Sittard | ||
| 12/09/2021 | FC Groningen vs. Heerenveen | ||
| 12/09/2021 | RKC Waalwijk vs. Vitesse | ||
| 01/12/2021 | Feyenoord vs. Heracles Almelo |